在完整的病理组织检测过程中技术错误的普遍性:系统性审查和元分析
Amanda Katsma1,2, Julie M Jorns2, Patrick Gardner2
1Clinical Research, University of Jamestown, Fargo, North Dakota, USA amanda.katsma@uj.edu.
BMJ open quality
|February 6, 2026
概括
病理组织处理中的技术错误比报告更常见,可能会影响患者的诊断. 需要标准化的方法来准确地检测和报告这些错误.
科学领域:
- 病理学 病理学 病理学
- 实验室医学 实验室医学
- 提高质量 提高质量
背景情况:
- 病理组织样本总检测过程中的技术错误可能会危及患者的诊断.
- 由于缺乏标准化检测和报告方法,这些错误的真实流行率往往被低估.
研究的目的:
- 估计病理组织样本分析整个工作流程中技术错误的普遍性.
- 突出未经记录和未确定的错误对诊断准确性的影响.
主要方法:
- 对2003年以后发表的观察性研究进行了系统审查和元分析.
- 来自31项研究的数据,包括超过270万例外科病理病例,使用随机效应模型进行了聚合.
- 在PubMed,CINAHL,Cochrane图书馆和Science Direct进行了搜索.
主要成果:
- 预分析错误的综合流行率为每1000例16.71.
- 积极发现的实验室错误发生率为每1000例中有40.17例.
- 报告的外科病理样本错误率为每1000例4.94,污染率为每1000例62.23.
结论:
- 组织加工中的技术错误可能比目前记录的更为普遍.
- 缺少标准化的错误定义和检测方法导致报告不足.
- 改进错误检测和报告对于确保可靠的实验室结果和保护患者诊断至关重要.
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