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Updated: Feb 11, 2026

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在分子动力学模拟中,两个Fab分子之间的热点相互作用改善了聚合动力学的预测模型.

Yuhan Wang1, Hywel D Williams2, Duygu Dikicioglu1

  • 1Department of Biochemical Engineering, University College London, London Wc1e 6bt, U.K.

Molecular pharmaceutics
|February 9, 2026
PubMed
概括

在蛋白质与蛋白质相互作用 (PPI) 中,确定关键的相互作用部位至关重要. 这项研究表明,持续接触点,而不仅仅是表面相互作用,对于预测蛋白质聚合和指导蛋白质工程来提高稳定性至关重要.

关键词:
抗体聚合 抗体聚合热点地区是热点地区.模型建筑模型建筑分子动力学模拟,分子动力学模拟多个抗体碎片中的多个抗体碎片.蛋白质与蛋白质的相互作用 (PPI)

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