Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mechanical Protein Functions01:58

Mechanical Protein Functions

5.7K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.7K
Three-Dimensional Force System01:30

Three-Dimensional Force System

2.9K
In mechanical engineering, a three-dimensional force system is a system of forces acting in three dimensions, with forces applied along the x, y, and z coordinate axes. The three-dimensional force system is an important concept in mechanical engineering, as it allows engineers to understand and analyze the behavior of objects and structures in three dimensions. By understanding the forces acting on a system, engineers can design more efficient and effective mechanical systems that can withstand...
2.9K
Three-Dimensional Force System:Problem Solving01:30

Three-Dimensional Force System:Problem Solving

1.4K
A three-dimensional force system refers to a scenario in which three forces act simultaneously in three different directions. This type of problem is commonly encountered in physics and engineering, where it is necessary to calculate the resultant force on the system, which can then be used to predict or analyze the behavior of the object or structure under consideration.
To solve a three-dimensional force system, first resolve each force into its respective scalar components. Do this using...
1.4K
Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

2.7K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.7K
Equilibrium Conditions for a Particle01:23

Equilibrium Conditions for a Particle

2.3K
When an object is in equilibrium, it is either at rest or moving with a constant velocity. There are two types of equilibrium: static and dynamic. Static equilibrium occurs when an object is at rest, while dynamic equilibrium occurs when an object is moving with a constant velocity. In both cases, there must be a balance of forces acting on the object.
To understand the concept of equilibrium, let us first consider the forces acting on an object. When different forces act on an object, they can...
2.3K
Non-conservative Forces01:17

Non-conservative Forces

10.0K
Non-conservative forces are dissipative forces such as friction or air resistance. These forces take energy away from a system as it progresses. Unlike conservative forces, non-conservative forces do not have potential energy associated with them. This is because the energy is lost to the system and cannot be turned into useful work later.
Also unlike their conservative counterparts, they are path-dependent; where the object starts and stops does matter. For example, a grinding wheel applies a...
10.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>In Vitro</i> Evolution of the Adenosine A<sub>2A</sub> Receptor Based on an Antagonist Binding Using a Ribosome Display.

Journal of the American Chemical Society·2026
Same author

The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Tandem Allosteric Effects of Reactant and Product that Promote Deacetylation Cycles in Sir2.

Journal of chemical information and modeling·2025
Same author

Author Correction: Balancing G protein selectivity and efficacy in the adenosine A<sub>2A</sub> receptor.

Nature chemical biology·2024
Same author

Balancing G protein selectivity and efficacy in the adenosine A<sub>2A</sub> receptor.

Nature chemical biology·2024
Same author

The influence of twist angle on the electronic and phononic band of 2D twisted bilayer SiC.

RSC advances·2023
Same journal

Impact of an Artificial Albumin Corona on Surface Charge-Driven Nano-Bio Interactions and Cytotoxicity of Silver Nanoparticles.

ACS omega·2026
Same journal

Structural and Functional Disruption of Thiopurine S‑Methyltransferase by the A80P Variant: A Simulation and Genotyping Study.

ACS omega·2026
Same journal

CRISPR/Cas12a2-Mediated Ultrasensitive Assay for Rapid Detection of H1N1 Influenza Virus RNA.

ACS omega·2026
Same journal

Photocatalytic Treatment of Real Sugar Industry Wastewater Using Lignocellulosic Biomass-Derived Hydrochar/g-CN.

ACS omega·2026
Same journal

Electrochemical Dopamine Biosensor Based on Plant-Derived Peroxidase Immobilized on Titanate Nanowires.

ACS omega·2026
Same journal

Revealing the Effects of Process Parameters on Structural, Thermal, Mechanical, Biodegradation, and Biocompatibility Properties on the Electrospinning of Poly(vinyl alcohol)/Microbial Inulin Nanofibers.

ACS omega·2026
查看所有相关文章

相关实验视频

Updated: Feb 17, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.2K

使用现代经典蛋白质力场重新审视真空模拟.

Vi Toan Lam1, Duy Phuoc Tran1

  • 1School of Life Sciences and Technology, Institute of Science Tokyo (formerly, Tokyo Institute of Technology), 2-12-1 Ookayama, Meguro-Ku, Tokyo 152-8550, Japan.

ACS omega
|February 16, 2026
PubMed
概括
此摘要是机器生成的。

现代生物分子力场在真空模拟中表现不清楚. 间残留相互作用,而不是CMAP或二面角,显著影响真空中的样采样,有助于未来的力场发展.

更多相关视频

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.8K
Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

898

相关实验视频

Last Updated: Feb 17, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.2K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.8K
Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

898

科学领域:

  • 生物分子模拟的模拟.
  • 计算化学是一种计算化学.
  • 蛋白质动力学 蛋白质动力学

背景情况:

  • 经典的生物分子力场已被广泛改进,用于溶液模拟.
  • 它们在真空模拟中的表现,对于理解内在性质至关重要,仍然不太了解.

研究的目的:

  • 在真空模拟中比较最近现代生物分子力场的性能.
  • 为了研究力场元件对样和形态空间的影响.

主要方法:

  • 对九种进行了广泛的复制交换分子动力学 (REMD) 模拟.
  • 量子力学 (QM) 总能计算用于验证模拟结果.
  • 分析包括采样形状,主要组件 (PC) 空间,旋转半径和N端到C端的距离.

主要成果:

  • 对CHARMM-GUI CMAP (校正地图) 或二面角函数的处理没有显著影响真空模拟采样.
  • 发现残留物之间主链侧链相互作用在真空模拟中起着重要作用.
  • 虽然个人并不总是占主导地位,但ff14SB力场在所有研究的中累计显示了最高的采样量.

结论:

  • 间残留物相互作用对于真空中精确的生物分子力场性能至关重要.
  • 当前的力场可能需要改进这些相互作用的建模,以提高可转移性.
  • 研究结果为开发未来的通用和可转移的生物分子力场提供了洞察力.