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头发中的乙基葡萄化物:十年的概述
Sara Casati1,2, Alessandro Ravelli1, Roberta F Bergamaschi1
1Laboratorio di Tossicologia Forense, Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università Degli Studi di Milano, Milan, Italy.
Drug testing and analysis
|February 19, 2026
概括
这项研究分析了68000多个样本的头发乙基葡萄化物 (EtG),以评估长期酒精消费趋势. 结果显示EtG水平因人口结构和季节而异,证实了头发EtG测试.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 成 药物 药物 药物 药物
背景情况:
- 头发乙基葡萄化物 (EtG) 分析提供了一种可靠的方法来评估长期的酒精消费.
- 了解EtG分布模式对于解释戒断和消费水平至关重要.
- 之前的研究已经探讨了EtG,但缺乏来自不同人群的大规模,长达十年的数据.
研究的目的:
- 评估长期的酒精消费模式,使用头发EtG分析在10年的时间.
- 调查人口因素 (年龄,性别),季节性和COVID-19流行病对EtG水平的影响.
- 通过使用已确定的切断值来评估头发EtG测试的可靠性和可比性.
主要方法:
- 从2013年至2022年从意大利北部的一个队列中收集的68,221个头发样本的回顾性分析.
- 使用高性能液体染色学-质谱法/质谱法 (HPLC-MS/MS) 来量化头发的EtG.
- 基于头发测试协会 (SoHT) 禁酒,反复和慢性过度饮酒的切断值的EtG水平的分类.
主要成果:
- 13.6%的样本显示重复饮酒 (5 < EtG < 30 pg/mg) 和5.6%显示慢性过度饮酒 (EtG ≥ 30 pg/mg).
- 根据性别,年龄,头发类型 (头部,胸部,下,部),头发段长度和季节 (在寒冷的月份更高) 显示出EtG水平的显著变化.
- 虽然没有观察到短期的COVID-19影响,但通过头发EtG检测到大流行对酒精消费的长期影响.
结论:
- 头发EtG测试是监测长期酒精消费的可靠方法,尽管度固有的变化.
- 人口因素,季节性和长期的社会事件,如COVID-19大流行,显著影响酒精消费模式.
- 这项研究为大量受监测的人群中酒精消费趋势提供了宝贵的见解,有助于临床和法医解释.
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