微型和纳米塑料作为潜在的中风风险因素:系统审查
Jakub Kufel1, Miłosz Korbaś2, Julita Janiec2
1Department of Radiology and Nuclear Medicine, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Journal of xenobiotics
|February 20, 2026
概括
微塑料和纳米塑料 (MNP) 存在于人体血管和中风血块中. 斑块中MNP的存在增加了心血管事件的风险,这表明它们可能是一个新的中风风险因素.
科学领域:
- 环境健康 环境健康
- 神经学 神经学
- 心血管科学 心血管科学
背景情况:
- 微塑料和纳米塑料 (MNPs) 的污染是一个日益严重的全球健康问题.
- 有证据表明,MNP存在人体内,但它们在脑血管疾病中的作用尚不清楚.
- 在全球范围内,中风仍然是导致死亡和残疾的主要原因.
研究的目的:
- 系统地审查血管系统中MNP的存在.
- 评估MNP与中风风险和进展之间的关联.
- 探索将MNP与脑血管事件联系起来的潜在生物机制.
主要方法:
- 按照PRISMA 2020指南进行系统的文献审查.
- 在PubMed,Scopus,Web of Science和Embase搜索了过去10年发表的研究.
- 包括5项研究 (2项人类观察,3项动物体内) 和评估方法质量.
主要成果:
- 在人动脉动脉样硬化斑块和中风血栓中检测到MNP,特别是聚乙烯和聚乙烯.
- 斑块中MNP的存在与重大心血管事件和死亡风险增加4.5倍相关.
- 动物研究表明,MNP暴露会导致微栓塞,血脑屏障破坏,并恶化缺血性损伤.
结论:
- 许多MNP在心血管系统中积累,并与包括中风在内的不良临床结果有关.
- 虽然MNP负担可能反映了累积暴露,但它们可能代表一种新的,可修改的中风风险因素.
- 需要进一步的标准化研究来确认MNP和中风之间的因果关系.
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