与COVID-19相关的嗅觉功能障碍和经典的病毒后嗅觉功能障碍的比较分析:一个多中心的回顾性研究.
T Miwa1, K Tsuzuki2, I Suzaki3
1Department of Otorhinolaryngology, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Rhinology
|February 20, 2026
概括
来自COVID-19 (COVID-19-OD) 的嗅觉功能障碍 (OD) 与后病毒性OD (PVOD) 不同,患者年轻,症状明显. COVID-19-OD的严重程度较轻,并因病毒变种而异,这表明生物差异.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 嗅觉功能障碍 (OD) 是一种常见的COVID-19症状,但其特征与传统的后病毒性OD (PVOD) 不同.
- COVID-19-OD的特征也因病毒亚型而异,需要进行比较分析.
研究的目的:
- 为了比较COVID-19-OD和PVOD之间的临床特征和嗅觉功能.
- 为了调查COVID-19变种中OD特征的差异.
主要方法:
- 一项多中心回顾性研究比较了269名COVID-19-OD患者 (2020-2022) 与380名PVOD患者 (2017-2019).
- 分析包括患者人口统计,嗅觉裂状况和医疗记录中的嗅觉功能.
主要成果:
- 与PVOD患者相比,COVID-19-OD患者的年龄更小,嗅觉裂阻塞率更高,帕洛斯米亚/幻体质更高.
- 在COVID-19-OD中,OD的严重程度较轻,即使经过年龄调整.
- 在Omicron前的COVID-19-OD病例比Omicron病例更年轻,并具有较高的帕洛斯米亚/索米亚率.
结论:
- COVID-19-OD和PVOD在临床表现和OD病理生理学上表现出显著差异.
- 跨变体的COVID-19-OD内部变异表明潜在的病毒生物差异影响嗅觉功能障碍.
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