Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

6.9K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.9K
Introduction to Actin01:26

Introduction to Actin

6.8K
Actin is a highly conserved cytoskeletal protein found abundantly in eukaryotic cells. It constitutes 10% weight of the total cellular protein in muscle cells, while in non-muscle cells, it is lower and makes up around 1–5 percent of the total cell protein. Actin found in the unicellular amoebae and complex multicellular animals is around 80% similar, demonstrating their conservation over a billion years of evolution.  Actin coding genes are conserved within species and across...
6.8K
The Role of Actin and Myosin in Non-muscle Cells01:10

The Role of Actin and Myosin in Non-muscle Cells

5.3K
Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
5.3K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

2.8K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Usefulness of the Brief Job Stress Questionnaire to identify employees at risk of depression in the Japanese Stress Check Program: a large-scale cross-sectional study.

Environmental and occupational health practice·2026
Same author

Integrating DNA Mutations and RNA Expression of Cancer Driver Genes in Asian Rare Cancers: A Pan-Cancer Analysis.

JCO precision oncology·2026
Same author

Genome-Wide Association Study of Vertical Jump Performance Among Elite Badminton Players.

International journal of molecular sciences·2026
Same author

Effects of squat training with different ranges of motion on muscle strength, jump performance, and change of direction ability.

The Journal of sports medicine and physical fitness·2026
Same author

Prospective association between high stress profile as defined using the Japanese Stress Check Program manual and long-term sickness absence among a working population with various backgrounds: a two-wave longitudinal study.

Environmental and occupational health practice·2025
Same author

Use of the ME-BYO Index, a Mobile Health App, During an Online Strength Training Program in Adults: Fidelity, Feasibility, and Acceptability Study.

JMIR human factors·2025

相关实验视频

Updated: Feb 28, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease
05:58

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Published on: July 15, 2014

41.5K

ACTN3基因型与肌肉功能的关联:系统性审查和元分析.

Mika Kamiya-Saito1, Hirofumi Zempo2, Kathleen Yasmin de Almeida3

  • 1Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.

International journal of sports medicine
|February 25, 2026
PubMed
概括

ACTN3 R577X基因变异与肌肉强度和功率有关. 具有RR,RX和XX基因型的个体表现出更高的一次重复最大,最大自愿收缩和跳跃性能.

更多相关视频

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.8K
Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

27.6K

相关实验视频

Last Updated: Feb 28, 2026

Tissue Triage and Freezing for Models of Skeletal Muscle Disease
05:58

Tissue Triage and Freezing for Models of Skeletal Muscle Disease

Published on: July 15, 2014

41.5K
Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.8K
Myo-mechanical Analysis of Isolated Skeletal Muscle
08:42

Myo-mechanical Analysis of Isolated Skeletal Muscle

Published on: February 22, 2011

27.6K

科学领域:

  • 遗传学和体育科学 遗传学和体育科学
  • 人体生理学 人体生理学
  • 分子生物学分子生物学

背景情况:

  • ACTN3基因R577X多态影响α-actinin-3的表达,α-actinin-3是一种对肌肉功能至关重要的蛋白质.
  • 以前的研究表明,ACTN3基因型和运动表现之间存在联系,特别是在力量和力量方面.

研究的目的:

  • 系统地审查和元分析ACTN3 R577X多态和肌肉强度和功率指标之间的关联.
  • 为了澄清肌肉性能变化的遗传基础.

主要方法:

  • 在PubMed和Web of Science的系统文献搜索到2025年10月15日.
  • 纳入标准:英语出版物,健康参与者,评估肌肉功能,以及ACTN3 R577X基因型分析.
  • 53篇文章的元分析,检查了结果,如一次重复的最大值,跳跃性能和最大自愿收缩.

主要成果:

  • 在添加模型中,在ACTN3 R577X多态和一次重复最大,最大自愿收缩和跳跃性能之间发现了显著的关联.
  • 在这些指标中,RR,RX和XX基因型的表现更高 (p < 0.01).
  • 对于其他测试的肌肉功能的测量,没有发现任何显著的关联.

结论:

  • ACTN3 R577X多态性与肌肉强度和功率的关键指标有关,特别是一次重复的最大,最大自愿收缩和跳跃性能.
  • 对这些绩效指标的遗传影响在男性中可能更为明显.
  • 这一发现有助于理解运动潜力的遗传基础.