同型半素,维生素B12,叶酸和偏头痛之间的关联:更新的系统性审查和元分析
Islamia Ibrahim Ahmed Omer1, Eman A Kubbara2, Tassneem Awad Hajali1
1Department of Clinical Science, College of Medicine, Sulaiman AlRajhi University, AlBukayriah 51941, Qassim, Saudi Arabia.
Brain sciences
|February 27, 2026
概括
偏头痛患者表现出更高的同类氨酸 (Hcy) 和更低的维生素B12和叶酸水平. 纠正这些可能有助于预防和治疗偏头痛.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 遗传学 遗传学 是一个
背景情况:
- 偏头痛是一种复杂的神经血管疾病.
- 它的发病可能与高水平的同类氨酸 (Hcy) 和维生素B12和叶酸缺乏有关.
- 之前关于这些关联的研究仍然没有结论.
研究的目的:
- 系统地审查和更新关于同类氨酸,维生素B12,叶酸和偏头痛之间的关联的证据.
- 为了澄清这些关系在成人和儿科人口.
主要方法:
- 在PubMed,ScienceDirect,Google Scholar和Cochrane图书馆进行了全面的文献搜索.
- 使用R软件进行的元分析计算了偏头痛病例与对照病例中Hcy,维生素B12和叶酸水平的标准化平均差异 (SMD).
- 包括的研究范围从开始到2025年12月.
主要成果:
- 对17项研究的元分析 (1549例偏头痛病例,1824例对照) 显示,偏头痛患者的Hcy水平显著更高 (SMD = 0.48).
- 在欧洲研究和使用非免疫检测方法的研究中,分层显示出一致的趋势.
- 与对照组相比,在偏头痛病例中观察到血清维生素B12 (SMD = -0.36) 和叶酸 (SMD = -0.25) 的水平明显降低.
结论:
- 成人和儿科的偏头痛患者表现出高水平的homocysteine以及降低的维生素B12和叶酸水平.
- 检查和纠正这些水平可能是对偏头痛管理的有价值的预防和治疗策略.
- 建议进行进一步的纵向研究以确定因果关系.
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