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流行性巨细胞衰老有助于在环境压力下降的精子运动性
Xin-Run Wang1,2, Hao Li1,2,3, Yong-Wei Xiong1,2
1Department of Toxicology, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei 230000, China.
Science advances
|February 27, 2026
概括
环境中的毒素,如,和,通过引起皮膜巨细胞的衰老来损害精子的运动性. 清除这些老化的细胞可以帮助预防由环境压力引起的男性不孕症.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 环境健康 环境健康
背景情况:
- 男性不孕症是一个日益严重的公共卫生问题,通常与环境因素有关.
- 精确的免疫机制背后的环境压力诱导的精子运动率的减少还没有完全理解.
- 诸如,和之类的重金属被认为是导致精子运动率下降的重要因素.
研究的目的:
- 调查免疫路径,将环境压力因素与精子运动率降低联系起来.
- 为了确定 epididymal 巨细胞在环境压力引起的男性不孕症中的作用.
- 探索针对巨细胞衰老的潜在治疗策略.
主要方法:
- 使用暴露于,和的体内和体外模型的实验.
- 分析巨细胞衰老标记物和尾膜中的Foxo3表达.
- 研究N6-甲基氨酸修饰Foxo3和FTO活动的作用.
- 评估Fto过度表达和S-adenosylhomocysteine补充剂的影响.
主要成果:
- 环境压力因素 (,,) 显著降低了精子的运动性.
- 环境压力会诱导皮质膜巨细胞的衰老.
- 清除衰老的巨细胞可以缓解由压力引起的精子运动率下降.
- 巨衰老是由由于增加N6-甲基氨酸水平和FTO抑制而导致的Foxo3表达的下调调节介导的.
- 调节FTO活性或S-adenosylhomocysteine水平可以减轻压力诱导的巨细胞衰老.
结论:
- 流行性巨细胞衰老是环境压力引起的男性不孕症的关键因素.
- 准和清除衰老的外皮膜巨细胞为预防男性不孕症提供了一种新的策略.
- 了解Foxo3-N6-甲基氨酸-FTO通路为男性生殖健康提供了洞察力.
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