尿氨基酸分析作为前列腺癌的非侵入性诊断和风险分层工具.
Tereza Zdobinska1, Hana Luksanova2, Katerina Duskova3
1Department of Urology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; tereza.zdobinska@fnmotol.cz.
In vivo (Athens, Greece)
|February 27, 2026
概括
尿氨基酸分析对检测前列腺癌 (PCa) 和提高诊断准确性显示出希望. 这种非侵入性方法可以通过补充前列腺特异性抗原 (PSA) 测试来帮助减少不必要的活检.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
背景情况:
- 前列腺癌 (PCa) 是男性的主要恶性瘤.
- 前列腺特异性抗原 (PSA) 测试具有有限的特异性,导致不必要的活检.
- 泌尿代谢分析提供了一种非侵入性方法来检测PCa相关的代谢变化.
研究的目的:
- 评估尿中氨基酸度,以区分PCa与良性疾病.
- 评估氨基酸在识别高风险PCa方面的潜力.
- 为了确定氨基酸水平是否提供诊断信息,独立于前列腺体积或先前操纵.
主要方法:
- 收集了90名男性 (60名PCa,30名对照) 的第一天早上的尿样,没有事先操纵前列腺.
- 使用高性能液体染色学量化尿液氨基酸总量.
- 分析了氨基酸度与PCa之间的关联,风险因素和临床参数.
主要成果:
- 在PCa患者中观察到谷氨酸+谷氨酸,氨酸,白氨酸和氨酸的显著变化.
- 氨酸表现出高的区分性表现 (AUC=0.79).
- 将尿氨基酸与PSA结合起来,显著提高了诊断准确度.
- 特定的氨基酸 (氨酸,氨酸) 与疾病特征相关,如节点阳性和高风险状态.
结论:
- 尿氨基酸分析是PCa诊断PSA测试的一个有希望的非侵入性补充.
- 这种方法可以提高诊断特异性,特别是对于边界PSA水平的男性.
- 没有事先操纵的患者友好的尿样增加了门诊的适用性,需要多中心验证.
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