我们是否错过了早期的胰腺功能障碍? 扩大便弹性酶测试范围,超越胰腺疾病
Connor E M Cotton1, Andrew D Hopper1,2, David S Sanders1,2
1Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals.
Current opinion in gastroenterology
|March 5, 2026
概括
胰腺外分缺陷 (PEI) 在患有胃肠道问题的患者中很常见. 通过便弹性酶-1 (FE-1) 测试进行早期检测,可以确定胰腺功能障碍,以便及时进行干预.
科学领域:
- 胃肠病学 胃肠病学
- 胰腺学 胰腺学
- 内部医学 内部医学
背景情况:
- 胰腺外分缺陷 (PEI) 通常与胰腺疾病有关,但在具有一般胃肠道症状的患者中诊断不足.
- 与诸如乳病,IBD和IBS等疾病的重叠症状可以推迟PEI诊断.
研究的目的:
- 审查胃肠病学队伍中PEI的流行情况.
- 评估便弹性酶-1 (FE-1) 测试的性能和实用性.
- 探索患有刺激性肠综合征 (IBS) 类型症状的患者的PEI,并讨论2025年欧洲指南的更新.
主要方法:
- 对流行数据的系统审查.
- 关于FE-1表现的元分析.
- 对IBS型患者PEI队列数据的分析.
主要成果:
- 在未经选择的胃肠病学队列中,PEI的患病率在11-21%之间.
- FE-1测试显示了中度至严重PEI的高灵敏度;重复测试可以澄清边界结果.
- 在一些IBS型患者中,PEI可能表明早期的胰腺功能障碍,提供了干预机会.
结论:
- PEI的相关性超出了原发性胰腺疾病的范围.
- 积极的FE-1测试可以提前识别和干预胰腺功能障碍.
- 早期识别可能允许在胰腺功能障碍的潜在可逆阶段改变生活方式.
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