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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Mar 6, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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针对I型干扰干扰素-IL-27信号的向,在复发性-缓解性多发性硬化症中拯救T调控细胞抑制功能.

Manal Elzoheiry, Maryam Seyedsadr, John Wrobel

    bioRxiv : the preprint server for biology
    |March 5, 2026
    PubMed
    概括

    来自复发性复发性多发性硬化症 (RRMS) 患者的调节性T细胞 (Tregs) 由于I型IFN和IL-27信号传输减少,其功能受损. 在体外和体内IL-27刺激恢复了Treg功能,这表明MS治疗的治疗潜力.

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    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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    相关实验视频

    Last Updated: Mar 6, 2026

    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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    Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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    Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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    科学领域:

    • 免疫学 免疫学 免疫学
    • 神经免疫学 神经免疫学
    • 细胞和分子医学是细胞和分子医学.

    背景情况:

    • 调节性T细胞 (Tregs) 对于免疫恒温至关重要.
    • 复发性复发性多发性硬化症 (RRMS) 患者的Tregs表现出抑制功能受损.
    • 导致RRMS Treg功能障碍的分子机制尚未完全理解,特别是关于I型干扰素 (IFN) 和IL-27信号通路.

    研究的目的:

    • 调查RRMS中Treg功能障碍的分子机制.
    • 探索针对IFN和IL-27信号通路的治疗潜力,以恢复RRMS中的Treg功能.
    • 通过调节Treg功能来评估cGAMP载荷微粒 (MPs) 在改善实验性自身免疫脑膜炎 (EAE) 的疗效.

    主要方法:

    • 从RRMS患者和健康对照组 (HCs) 的Tregs的单细胞RNA测序 (scRNAseq).
    • 用cGAMP-MPs对EAE模型进行治疗,以激活IFN基因刺激器 (STING) 途径.
    • 使用Treg特定的IL-27R淘汰赛小鼠 (Treg ΔIl27ra) 的基因操纵.
    • 在体外IL-27刺激RRMS衍生的Tregs.

    主要成果:

    • RRMS Tregs显示I型IFN和IL-27信号通路的下调,IFN刺激基因 (ISG) 和关键Treg抑制媒介的表达减少.
    • 通过诱导表达IL-27R,IL-10,TGF-b和Granzyme B的Tregs,cGAMP-MP治疗改善了EAE.
    • 在EAE中,cGAMP-MP治疗的治疗效果取决于IL-27信号,因为它在Treg ΔIl27ra小鼠中被废除了.
    • 在体外IL-27刺激恢复了RRMS Tregs中IFN通路基因和Treg抑制基因的表达.

    结论:

    • 降低I型IFN和IL-27信号传递有助于RRMS中的Treg功能障碍.
    • 用cGAMP-MPs激活STING通路可以恢复Treg抑制功能并改善EAE,突出显示IL-27信号传递的作用.
    • 在RRMS的未来临床应用中,IL-27预刺激有望恢复Treg抑制功能并增强它们向中枢神经系统 (CNS) 的迁移.