小肠细菌过度生长和肠道甲素过度生长:它们是否被过度诊断?
Anokhi S Kholwadwala1, Eamonn M M Quigley2
1Bachelor of Science, Master of Science.School of Engineering Medicine, Texas A&M University, Houston, Texas, USA. Texas A&M University Texas A&M University HoustonTexas USA.
Acta gastroenterologica Latinoamericana
|March 13, 2026
概括
小肠细菌过度生长 (SIBO) 的过度诊断是常见的,因为人们依赖呼吸测试. 建议谨慎对待诊断和抗生素的使用,等待进一步的研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 消化系统健康 消化系统健康
背景情况:
- 小肠细菌过度生长 (SIBO) 历史上与消化不良/吸收不良有关,通过小肠上部吸附培养诊断.
- 气呼吸测试的出现大大增加了SIBO诊断,将其范围扩大到非特异性胃肠道和全身疾病.
- 目前的诊断方法,特别是乳糖呼吸测试,被质疑可能导致SIBO过度诊断.
研究的目的:
- 批判性地审查细肠细菌过度生长 (SIBO) 的诊断.
- 解决有争议的问题,包括诊断门,抗生素反应,以及甲等其他气体的作用.
- 探索肠道甲素过度生长 (IMO) 以及甲素和甲在胃肠道平衡中的作用.
主要方法:
- 文献综述侧重于SIBO的诊断标准和治疗反应.
- 对呼吸试验方法的批判性分析,特别是基于乳糖的气呼吸试验.
- 在胃肠道健康的背景下探讨甲和甲原体的作用.
主要成果:
- 有证据表明,呼吸试验,特别是乳糖,可能导致SIBO的过度诊断.
- 关键的诊断方面,如值和对抗生素的反应仍然没有解决.
- 在SIBO诊断中甲,硫化和其他气体的重要性需要进一步调查.
结论:
- 建议对诊断SIBO和IMO采取批判性和谨慎的方法.
- 建议对SIBO和IMO进行明智的抗生素使用.
- 未来利用分子微生物学的研究是必要的,以充分了解小肠微生物组,代谢组和甲生物学.
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