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Updated: Mar 17, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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一种基于核密度估计的方法,用于从基因表达数据量化癌症中的O-GlcNAcylation失调

Rastko Stojšin1, Jinlian Wang1, Hongfang Liu1

  • 1Center for Translational AI Excellence and Applications in Medicine, D. Bradley McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

Bioinformatics advances
|March 16, 2026
PubMed
概括

癌症中的O-GlcNAcylation失调现在可以使用O-GlcNAc转移酶 (OGT) 和O-GlcNAcase (OGA) 表达量化. 这种基于转录组学的新方法准确地推断和分类癌症状态,为大规模研究提供了可扩展的方法.

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相关概念视频

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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