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Updated: Jul 25, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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在人类病理性血清中检测循环免疫复合体

A H Johnson, J F Mowbray, K A Porter

    Lancet (London, England)
    |April 5, 1975
    PubMed
    概括

    研究人员使用补充成分1 (C1) 结合试验检测出循环中的免疫复合体. 一些患者含有核酸的抗补综合体,可能与病毒抗原和免疫复杂血管疾病有关.

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    Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...