神经质之间间隙连接的单向合
S R Robinson1, E C Hampson, M N Munro
1Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia.
概括
在子视网膜中,间隙结允许星体细胞,寡体细胞和穆勒细胞之间的通信. 染料转移大多是从星球细胞的单向转移,这表明细胞层次结构.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 眼科医生 眼科 眼科
背景情况:
- 间隙连接通过离子和小分子通道促进直接的细胞间通信.
- 在像视网膜这样的复杂组织中,了解细胞对细胞的通信至关重要.
研究的目的:
- 研究子不同类型的视网膜细胞之间的细胞间通信的方向性.
- 探索间隙连接透性的潜在不对称性.
主要方法:
- 使用低分子量染料 (露西弗黄色,生物) 进行子视网膜扩张器的细胞间追踪.
- 观测到天体细胞,寡细胞和米勒细胞之间的染料运动.
主要成果:
- 染料很容易从星体细胞传递到寡聚体细胞和米勒细胞.
- 染料从寡细胞或米勒细胞转移回天体细胞是最小的.
- 证明了单向的染料运动,表明不对称的透性.
结论:
- 在子视网膜中的异质间隙连接处表现出不对称的分子屏障.
- 这种不对称性表明,视网膜质细胞之间信息流动的潜在层次结构.
相关概念视频
Contact-dependent Signaling
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
Glial Cells
Overview
Gap Junctions
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap Junctions
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
Overview of Synapses
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...


