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Distal myasthenia gravis.

S P Nations1, G I Wolfe, A A Amato

  • 1Department of Neurology, University of Texas Southwestern Medical School, Dallas 75235-8897, USA. snations@mednet.swmed.edu

Neurology
|February 20, 1999
PubMed
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Myasthenia gravis typically affects proximal muscles. However, this study found 3% of patients experienced significant distal extremity weakness, particularly in hand muscles.

Area of Science:

  • Neurology
  • Clinical Myology

Background:

  • Myasthenia gravis (MG) classically presents with ocular, bulbar, and proximal muscle weakness.
  • Distal extremity muscles are generally considered less affected in MG.

Observation:

  • A retrospective chart review of 236 MG patients was conducted at two neuromuscular clinics.
  • Nine patients (3%) exhibited distal extremity weakness more severe than proximal weakness.

Findings:

  • The predominant weakness in these nine patients involved hand muscles, especially finger extensors.
  • Distal leg and foot muscles were less frequently involved compared to hand muscles.

Implications:

  • This finding challenges the typical presentation of myasthenia gravis.

Related Experiment Videos

  • Highlights the importance of assessing distal muscle strength in MG patients for a comprehensive diagnosis.