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Updated: Aug 10, 2026
12:06
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Peripheral nerve tumors of the orbit
G S Carroll1, B G Haik, J C Fleming
1Department of Ophthalmology, University of Tennessee, Memphis, USA. gcarroll@mail.eye.utmem.edu
Radiologic Clinics of North America
|February 23, 1999
Summary
Orbital neurofibromas and schwannomas present similar features. While some are resectable, infiltrative types and malignant tumors have high recurrence and poor survival rates.
Area of Science:
- Ophthalmology
- Neurosurgery
- Pathology
Background:
- Orbital neoplasms, including neurofibromas and schwannomas, share clinical and radiologic characteristics.
- Different subtypes exhibit varying growth patterns and prognoses.
Purpose of the Study:
- To describe the clinical and radiologic features of peripheral nerve sheath tumors in the orbit.
Main Methods:
- Review of clinical presentations.
- Analysis of radiologic imaging.
- Pathologic correlation.
Main Results:
- Solitary/circumscribed neurofibromas and schwannomas: slow growth, ocular displacement, surgically resectable.
- Plexiform/diffuse neurofibromas: infiltrative, difficult resection, high recurrence.
- Malignant peripheral nerve tumors: rare, high recurrence, low 5-year survival due to potential midbrain extension.
Conclusions:
- Peripheral nerve sheath tumors in the orbit have diverse presentations and management challenges.
- Accurate diagnosis based on clinical and radiologic features is crucial for treatment planning and predicting outcomes.
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