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Specific determination of benzene in urine using dynamic headspace and mass-selective detection
G Ljungkvist1, M Lärstad, L Mathiasson
1Göteborg University, Institute of Internal Medicine, Section of Occupational Medicine, Sweden.
Abstract:
A method for the determination of benzene in urine was developed, based on dynamic headspace and preconcentration of the analyte on a solid sorbent. The subsequent analysis by thermal desorption of the sorbent, capillary gas chromatography and mass-selective detection ascertained a low limit of detection (6.5 ng/l) and a highly specific determination. The limit of detection is an order of magnitude lower than that reported earlier and allows reliable quantitation of occupational exposure and of most environmental exposures. Samples could be stored frozen for at least a month without significant loss.
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