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Related Experiment Videos

Transient thalamic changes on MRI in a child with hypernatremia.

D S Hartfield1, J A Loewy, J Y Yager

  • 1Department of Pediatrics, University of Saskatchewan, College of Medicine, Saskatoon, Canada.

Pediatric Neurology
|February 24, 1999
PubMed
Summary

Severe hypernatremia can cause brain lesions. This case highlights new bilateral thalamic signal changes in an infant after correction, questioning current treatment guidelines.

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Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Background:

  • Severe hypernatremia is linked to central nervous system (CNS) lesions.
  • Neurologic sequelae commonly follow neuroradiologically confirmed lesions.

Observation:

  • A 7-month-old male infant experienced obtundation post-correction of severe hypernatremia.
  • Magnetic resonance imaging (MRI) revealed bilateral thalamic signal changes.

Findings:

  • The thalamic signal changes resolved with complete clinical recovery.
  • These bilateral thalamic signal changes are a previously unreported finding in hypernatremia.

Implications:

  • The findings challenge current guidelines for the rate of hypernatremia correction.

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  • Further research is needed to understand the mechanism and optimal management of hypernatremia-induced CNS changes.