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Effect of chronic peritoneal fluid eosinophilia on peritoneal membrane function
A A Ejaz1, R I Zabaneh, T Ridlon
1Department of Medicine, Halifax Medical Center, Daytona Beach, Florida, USA.
JPMA. the Journal of the Pakistan Medical Association
|March 6, 1999
Summary
Long-term peritoneal fluid eosinophilia, a condition affecting nearly 40% of patients, did not significantly impact peritoneal dialysis function. This suggests eosinophils in peritoneal fluid may not harm the peritoneal membrane in dialysis patients.
Area of Science:
- Nephrology
- Peritoneal Dialysis
- Immunology
Background:
- Peritoneal fluid eosinophilia is a recognized condition in patients undergoing peritoneal dialysis.
- The clinical significance and impact of persistent eosinophilia on peritoneal membrane function remain incompletely understood.
Purpose of the Study:
- To investigate the long-term effects of persistent peritoneal fluid eosinophilia on peritoneal membrane function.
- To assess changes in dialysis adequacy parameters in patients with chronic eosinophilia.
Main Methods:
- A prospective study was conducted at a community-based peritoneal dialysis unit.
- Thirty-one patients were enrolled over a 9-month period, with chronic eosinophilia noted in 12 (38.7%).
- Key dialysis function markers including creatinine clearance, D/P urea, and Kt/V were compared to baseline values.
Main Results:
- No significant differences were observed in creatinine clearance, D/P urea, or Kt/V values compared to baseline in patients with long-term peritoneal fluid eosinophilia.
- The prevalence of chronic peritoneal fluid eosinophilia was 38.7% in the studied cohort.
Conclusions:
- Long-term persistent peritoneal fluid eosinophilia does not appear to significantly impair peritoneal membrane function in patients on maintenance peritoneal dialysis.
- Further research may elucidate the precise role and implications of peritoneal eosinophils in dialysis patients.