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Capacitative calcium entry channels.

J W Putney1, R R McKay

  • 1Calcium Regulation Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|March 10, 1999
PubMed
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Capacitative calcium entry, crucial for cell signaling, is activated by depleted intracellular calcium stores. Mammalian TRP proteins are investigated as potential channels for this calcium influx.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Physiology

Background:

  • Phospholipase C signaling involves calcium (Ca2+) mobilization from intracellular stores by inositol 1,4,5-trisphosphate.
  • Depletion of these stores triggers capacitative calcium entry (CCE) at the plasma membrane.
  • The precise signal activating CCE remains unidentified but may involve endoplasmic reticulum-derived factors.

Purpose of the Study:

  • To review current understanding of the signals that activate capacitative calcium entry.
  • To discuss the potential role of mammalian transient receptor potential (TRP) proteins in CCE.

Main Methods:

  • Literature review of recent research on capacitative calcium entry.
  • Analysis of studies investigating mammalian TRP proteins in calcium signaling.

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Main Results:

  • Research highlights mammalian homologues of Drosophila TRP proteins as candidates for CCE channels.
  • Evidence suggests a diffusible signal from the endoplasmic reticulum may activate CCE.

Conclusions:

  • Mammalian TRP proteins are key targets for understanding CCE channel function.
  • Further research is needed to elucidate the exact nature of CCE-activating signals.