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Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs
1Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
Aim:
To study effects of histamine on cardiomyopathy.
Methods:
Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine 0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 micrograms) was given by intra-aortic injection. Histamine content of coronary venous effluent was determined fluorometrically.
Results:
Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P < 0.01).
Conclusion:
Histamine aggravated levothyroxine-cardiomyopathy.