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Synthesis and anticonvulsant activity of 1,2-aminoalkanol derivatives
H Marona1, L Antkiewicz-Michaluk
1Department of Chemical Technology of Drugs Collegium Medicum of the Jagiellonian University, Kraków, Poland.
Acta Poloniae Pharmaceutica
|March 12, 1999
Abstract:
A series of 1,2-aminoalkanol derivatives were prepared and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Most interesting were the anticonvulsant results of S-(+)-2-amino-1-butanol derivative VIII, which displayed anti-MES activity with a protective index (TD50/ED50) of 4.55 corresponding with that for phenytoin, carbamazepine and valproate.