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A new amide from zanthoxylum armatum

Kalia1, Singh, Sood

  • 1Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur - 176 061 Himachal Pradesh, India.

Journal of Natural Products
|March 17, 1999
PubMed
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Researchers isolated a new compound, armatamide, from Zanthoxylum armatum bark. This study details its chemical structure and identifies other natural compounds present.

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Organic Chemistry

Background:

  • Zanthoxylum armatum is a plant species known for its diverse chemical constituents.
  • Natural products often possess unique biological activities and structural features.
  • Isolation and characterization of novel compounds contribute to the understanding of plant secondary metabolism.

Purpose of the Study:

  • To isolate and characterize novel chemical compounds from the bark of Zanthoxylum armatum.
  • To identify known lignans, triterpenoids, and sterols co-occurring with the new compound.
  • To elucidate the chemical structure of the newly discovered amide, armatamide.

Main Methods:

  • Phytochemical investigation of Zanthoxylum armatum bark extract.
  • Isolation of compounds using chromatographic techniques (e.g., column chromatography).

Related Experiment Videos

  • Structure elucidation through comprehensive spectral analysis (NMR, MS) and chemical methods.

    • Main Results:

    • A new amide, armatamide (1), was isolated and characterized.
    • Two known lignans, asarinin and fargesin, were identified.
    • Other isolated compounds include alpha- and beta-amyrins, lupeol, and beta-sitosterol-beta-D-glucoside.
    • The structure of armatamide was determined to be N-(4'-methoxyphenyl ethyl)-3, 4-methylenedioxy cinnamoyl amide.

    Conclusions:

    • The bark of Zanthoxylum armatum is a source of diverse natural products, including a novel amide.
    • Armatamide represents a new addition to the known chemical constituents of the Zanthoxylum genus.
    • The findings contribute to the chemotaxonomic understanding of Zanthoxylum species and provide potential leads for further pharmacological studies.