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Related Experiment Videos

Transdermal drug delivery: overcoming the skin's barrier function.

Naik1, Kalia, Guy

  • 1Centre Interuniversitaire de Recherche et d'Enseignement, Campus Universitaire, Parc d'Affaires International, F-74166, Archamps, France

Pharmaceutical Science & Technology Today
|September 21, 2000
PubMed
Summary

The skin acts as a protective barrier, preventing water loss and limiting molecular transport. Overcoming this barrier is crucial for advancing transdermal drug delivery technologies.

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Area of Science:

  • Dermatology and Pharmaceutical Sciences

Background:

  • The skin serves as a vital evolutionary adaptation, encapsulating organisms and mediating environmental interactions.
  • It functions as a sophisticated homeostatic barrier, crucial for preventing dehydration and maintaining internal stability.
  • The skin's inherent barrier properties restrict both the inward and outward passage of molecules.

Purpose of the Study:

  • To highlight the challenges and progress in overcoming the skin's barrier function for transdermal drug delivery.
  • To underscore the significance of the skin's barrier properties in pharmaceutical science.

Main Methods:

  • Review of existing literature on skin barrier function.
  • Analysis of advancements in transdermal drug delivery strategies.

Main Results:

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  • The skin's barrier is highly effective at preventing water loss and regulating molecular transport.
  • Significant progress has been made in developing methods to overcome the skin barrier for drug delivery.

Conclusions:

  • The skin's barrier function presents a substantial challenge for transdermal drug delivery.
  • Ongoing research and innovation continue to yield progress in this field.