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[Study of delayed hypersensitivity in experimental tick-borne encephalitis]
Experiments were conducted on albino mice. With the aid of the test of inhibition of splenocyte migration in the agar medium it was shown that the tick-borne encephalitis virus caused the state of hypersensitivity of delayed type (HDT) expressed from the 3rd day after the infection and persisting up to the appearance of the clinical signs of the disease; in latent infection the HDT state persisted for a period of up to 50 days (observation period). At the same time the experimental animals displayed a weak splenocyte sensitization with the brain tissue chiefly observed in cases of an acute infection and expressed inconstantly in the latten course of tick-borne encephalitis.
Experiments were conducted on albino mice. With the aid of the test of inhibition of splenocyte migration in the agar medium it was shown that the tick-borne encephalitis virus caused the state of hypersensitivity of delayed type (HDT) expressed from the 3rd day after the infection and persisting up to the appearance of the clinical signs of the disease; in latent infection the HDT state persisted for a period of up to 50 days (observation period). At the same time the experimental animals displayed a weak splenocyte sensitization with the brain tissue chiefly observed in cases of an acute infection and expressed inconstantly in the latten course of tick-borne encephalitis.