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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

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[FREQUENCY OF OCCURRENCE OF POLYMORPHIC VARIANTS OF IL28B GENE AND GENOTYPES OF HEPATITIS C VIRUS IN POPULATION OF

S I Semenov, A L Fedorov, V L Osakovsky

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 30, 2019
    PubMed

    Insights

    Hepatitis C virus (HCV) genotype and IL28B gene variants influence disease severity. HCV genotype 1b with specific IL28B polymorphisms indicates a milder disease course, while genotype 3a with other IL28B variants suggests a more aggressive presentation.

    Area of Science:

    • Hepatology
    • Virology
    • Genetics

    Background:

    • Chronic hepatitis C (HCV) is a significant global health concern.
    • Understanding the interplay between HCV genotypes and host genetic factors like IL28B gene polymorphisms is crucial for predicting disease progression and treatment outcomes.

    Purpose of the Study:

    • To investigate the clinical outcomes of chronic hepatitis C patients based on HCV genotype and IL28B gene polymorphisms.
    • To identify specific genetic profiles associated with disease severity and progression.

    Main Methods:

    • A cohort of 592 individuals was studied.
    • HCV RNA genotyping and IL28B gene single nucleotide polymorphism (SNP) genotyping (rs12979860 and rs8099917) were performed using PCR and real-time PCR.

    Main Results:

    • HCV genotype 1b was the most prevalent (74.2%), followed by genotype 3a (11.4%).
    • Common IL28B variants included rs12979860 CC (72.2%) and rs8099917 TT (61.1%).
    • Specific combinations of HCV genotype 1b with IL28B rs12979860 CC or rs8099917 CT were associated with less aggressive disease.

    Conclusions:

    • HCV genotype 3a combined with IL28B rs12979860 CC or rs809917 TT polymorphisms correlated with a more severe clinical presentation.
    • Certain IL28B variants (rs8099917 T/G, rs12979860 C/T) were linked to more severe outcomes, including high viral load and advanced liver disease (cirrhosis, hepatocarcinoma).
    Abstract

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