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Related Experiment Videos

Future prospects for artificial blood.

T M Chang1

  • 1Artificial Cells and Organs Research Centre, McGill University, Montreal, Quebec, Canada. http:/(/)www.physio.mcgill.ca/artcell

Trends in Biotechnology
|March 24, 1999
PubMed
Summary
This summary is machine-generated.

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Concerns about blood safety have led to the development of blood substitutes. Hemoglobin-based oxygen carriers and artificial red blood cells are advancing towards clinical application.

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Materials Science

Background:

  • Infective agents in donated blood pose a significant health risk.
  • The need for safe and effective blood transfusion alternatives is critical.

Purpose of the Study:

  • To review the progress and development of novel blood substitutes.
  • To highlight advancements in hemoglobin-based oxygen carriers and artificial red blood cells.

Main Methods:

  • Review of current research and clinical trial data on blood substitutes.
  • Analysis of chemical modifications and engineering of hemoglobin-based products.
  • Assessment of artificial red blood cell technologies.

Main Results:

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  • Chemically cross-linked hemoglobins are in late-stage clinical trials.
  • New hemoglobin generations are being developed to manage nitric oxide and oxygen radicals.
  • Artificial red blood cells represent a promising alternative under development.

    • Conclusions:

    • Blood substitutes are nearing clinical readiness, offering safer alternatives to transfusion.
    • Ongoing research focuses on improving the efficacy and safety profile of hemoglobin-based oxygen carriers.
    • Artificial red blood cells show potential for future clinical use.