Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microdissection-Based p53 Genotyping: Concepts for Molecular Testing.

Finkelstein1, Przygodzki, Swalsky

  • 1Department of Pathology, University of Michigan, Ann Arbor, Michigan

Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology
|March 25, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topographic mapping of the quantum hall liquid using a few-electron bubble

Science (New York, N.Y.)·2000
Same author

The Effect of Agmatine on Ischemic and Nonischemic Isolated Rat Heart.

Journal of cardiovascular pharmacology and therapeutics·2000
Same author

Oleg borisovich ptitsyn: july 18, 1929-march 22, 1999

Proteins·1999
Same author

Malignant Transformation in Sinonasal Papillomas Is Closely Associated With Aberrant p53 Expression.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology·1999
Same author

Adjuvant Chemotherapy in Advanced Head and Neck Cancer.

The oncologist·1997
Same author

NO2 adsorption on Grafoil between 297 and 12 K.

Physical review. B, Condensed matter·1996

Molecular testing for p53 gene mutations is now justified for specific cancer diagnostics. This approach integrates genetic analysis with histopathology for improved solid tumor diagnosis.

Area of Science:

  • Oncology
  • Molecular Genetics
  • Cancer Biology

Background:

  • The p53 gene is frequently altered in human cancers, playing a critical role in tumor development and progression.
  • Understanding p53 mutation patterns supports the development of targeted molecular diagnostic tests.

Purpose of the Study:

  • To outline specific concepts for molecular diagnostic testing of the p53 gene.
  • To emphasize considerations for solid tumor molecular diagnostics and quality control.

Main Methods:

  • Focus on microdissection-based fixed tissue molecular analysis.
  • Introduction of new quality control considerations for this methodology.

Main Results:

  • Established concepts for p53 molecular testing in solid tumors.

Related Experiment Videos

  • Highlighted the importance of quality control in fixed tissue analysis.

    • Conclusions:

    • Molecular diagnostic testing for p53 mutations is feasible and beneficial for specific objectives.
    • The proposed concepts can serve as a model for developing integrated histopathologic/genetic diagnostic assays.