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[New approaches to the chemotherapy of HIV infection]
E V Karamova1, I B Sakhuriia, M Iu Shelkanov
1Ivanovsky Research Institute of Virology, Moscow, Russia.
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|March 30, 1999
Abstract:
The preclinical analysis of the effectiveness of AZT and new compounds (sulphatized derivate of chitosan (Sch) and adamantileted Sch, contents 10 and 18% of adamantine) prepared on the basis of chitosan (Ch), carried out with the use of the experimental clinical test system (the in vitro model of peripheral blood mononuclears of a concrete patient) developed in laboratory, is presented. Both combinations in concentration 0.01 mkg/ml are decreased HIV antigens till 6.4 and 8.6% accordingly, while whilst initial Sch hare caused less effect in 4-5 fold.