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Related Experiment Videos

Teeth. Where and how to make them.

H Peters1, R Balling

  • 1GSF-Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany. hpeters@rascal.med.harvard.edu

Trends in Genetics : TIG
|March 31, 1999
PubMed
Summary
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Tooth development relies on molecular signaling between tissues. Mesenchymal transcription factors (Msx1, Pax9) initially respond to epithelial growth factors (FGFs, BMPs) but later control them, forming a regulatory cascade.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Organogenesis

Background:

  • Organ development requires precise spatial organization regulated by tissue interactions.
  • The developing mouse tooth serves as a model for studying organogenesis.
  • Reciprocal signaling between epithelium and mesenchyme is crucial for development.

Purpose of the Study:

  • To elucidate the molecular mechanisms controlling reciprocal tissue interactions during tooth organogenesis.
  • To understand the dynamic roles of signaling molecules and transcription factors in odontogenesis.

Main Methods:

  • Investigated signaling pathways involving Fibroblast Growth Factors (FGFs) and Bone Morphogenetic Proteins (BMPs).
  • Analyzed the roles of mesenchymal transcription factors Msx1 and Pax9.

Related Experiment Videos

  • Examined the temporal regulation of gene expression during different developmental stages.

    • Main Results:

    • Signaling molecules like FGFs and BMPs exhibit synergistic and antagonistic effects.
    • These growth factors have stage-specific functions and are regulated by upstream factors.
    • Msx1 and Pax9 are initially regulated by epithelial FGFs/BMPs but later act upstream of them.

    Conclusions:

    • A molecular cascade involving FGFs, BMPs, Msx1, and Pax9 regulates reciprocal tissue interactions in tooth development.
    • This cascade provides a model for understanding how tissue crosstalk is controlled during organogenesis.