A potent polyamine analog, spermindiol

The effects of spermine, putrescine, and spermindiol on different nucleases were investigated. A highly active spermine analog, spermindiol, was synthesized, which markedly enhanced DNA hydrolysis by staphylococcal nuclease and spleen DNase II [EC 3.1.4.6] and RNA degradation by staphylococcal nuclease and pancreatic RNase A [EC 3.1.4.22]. Spermindiol also increased the melting temperature of calf thymus DNA.