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Biocompatibility evaluation of glass ionomer cement using cell culture techniques
1Institute of Medical and Dental Bioengineering, University of Liverpool, UK.
Clinical Materials
|December 10, 1990
Abstract:
Cell culture techniques have been employed to carry out a preliminary investigation into the biocompatibility of a glass ionomer cement (GIC). A modification of the commonly used Agar Overlay test and a rapid, colorimetric assay based on the reduction of tetrazolium salt were used. The GIC is shown to leach a cytotoxic agent, possibly fluoride. This agent is effectively removed by an extraction procedure, and re-examination of the GIC demonstrates its cytocompatibility.