Aging effects on hypothalamic dopamine and norepinephrine content in the male rat

Hypothalamic content of dopamine and norepinephrine was measured in young (4 mo) and aged (24-26 mo) male rats by aluminum oxide adsorption and microfluorescence. Hypothalamic content of both dopamine and norepinephrine was significantly less in aged than in the young groups. Average dopamine content of the young and aged groups was 32.5 +/- 9.3 and 15.6 +/- 2.5 ng/hypothalamus, respectively. Norepinephrine content averaged 47.6 +/- 10.7 and 22.8 +/- 1.8 ng/hypothalamus in the young and aged groups. These data suggested that alterations in hypothalamic catecholamine function contribute to changes in endocrine control mechanisms during aging.