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Changes in anticoagulation in dogs assayed by three methods.

H N Harrison, B Gutterman, M Haynie

    Laboratory Animal Science
    |December 1, 1976
    PubMed
    Summary
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    Activated partial thromboplastin time (APTT) is a reliable indicator for monitoring coagulation in extracorporeal systems. This study found APTT and blood activated recalcification time (BART) superior to whole blood clotting time for experimental use.

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Cardiovascular Research

    Background:

    • Membrane oxygenator research requires reliable coagulation monitoring.
    • Existing clotting assays have limitations in experimental extracorporeal systems.

    Purpose of the Study:

    • To evaluate various clotting indices for monitoring coagulation in dogs during extracorporeal circulation.
    • To determine the most suitable assay for experimental membrane oxygenator studies.

    Main Methods:

    • Linear regression and correlation analysis were used to compare clotting indices.
    • Activated partial thromboplastin time (APTT), blood activated recalcification time (BART), and whole blood clotting time (WBCT) were assessed.
    • Dog data was correlated with existing human data.

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    Main Results:

    • APTT showed a significant correlation (0.77, p<0.01) with whole blood clotting time.
    • APTT and BART assays demonstrated reduced variability and faster determination compared to WBCT.
    • BART assay exhibited the lowest variability and sensitivity comparable to APTT.

    Conclusions:

    • APTT is a valuable and reliable criterion for monitoring coagulation in experimental extracorporeal systems.
    • APTT and BART are superior to WBCT for studies involving extracorporeal support due to efficiency and consistency.
    • The dog model is suitable for developing extracorporeal systems like membrane oxygenators, with APTT as a key monitoring tool.