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Related Experiment Videos

[Complement system during hemofiltration in patients with multiple organ failure].

I I Iakovleva, V S Timokhov, G V Lialikova

    Anesteziologiia I Reanimatologiia
    |April 13, 1999
    PubMed
    Summary
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    Patients with severe sepsis and multiple organ failure (MOF) experienced complement system depletion. Substitute renal therapy (SRT) via hemofiltration did not worsen this depletion, but complement fractions entered the filtrate.

    Area of Science:

    • Nephrology
    • Critical Care Medicine
    • Immunology

    Background:

    • Multiple organ failure (MOF) is a critical condition often associated with sepsis.
    • Patients with MOF frequently require intensive support, including mechanical ventilation and inotropic agents.
    • The complement system plays a crucial role in immune response and can be dysregulated in critical illness.

    Purpose of the Study:

    • To investigate the impact of substitute renal therapy (SRT) on the complement system in patients with multiple organ failure (MOF).
    • To assess the safety and effects of extracorporeal perfusion during SRT on a compromised immune system.

    Main Methods:

    • Treatment of nine critically ill patients (7 with sepsis) using permanent hemofiltration with spontaneous arteriovenous perfusion as SRT.

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  • Monitoring of the complement system status throughout the SRT process.
  • Analysis of complement fraction levels in the filtrate.

    • Main Results:

    • Patients exhibited significant depletion of the complement system, which worsened with the progression of MOF.
    • Extracorporeal perfusion during SRT did not cause additional damage to the already depleted complement system.
    • Individual complement fractions were detected in the filtrate, indicating nonselective penetration.

    Conclusions:

    • The complement system is severely impaired in patients with MOF.
    • SRT, specifically hemofiltration, does not exacerbate complement system damage in MOF.
    • The penetration of complement fractions into the filtrate during SRT suggests a potential interaction that may modulate therapy.