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Related Experiment Videos

Tissue transglutaminase: apoptosis versus autoimmunity.

M Piacentini1, V Colizzi

  • 1Dept of Biology, University of Rome Tor Vergata, Italy. mauro.piacentini@UniRoma2.it

Immunology Today
|April 22, 1999
PubMed
Summary

Post-translational modifications of proteins by tissue transglutaminase can impact autoimmunity. These modifications of antigens during apoptosis may trigger autoimmune responses involving autoantibodies and autoreactive T cells.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Autoimmune diseases involve autoantibodies and autoreactive T cells targeting numerous antigens.
  • Many autoantigens are modified post-translationally during apoptosis.
  • Proapoptotic cysteine proteases utilize these modified antigens as substrates.

Purpose of the Study:

  • To discuss the influence of post-translational modifications on autoimmunity.
  • To explore the role of tissue transglutaminase in catalyzing these modifications.

Main Methods:

  • Literature review and discussion of existing research.
  • Analysis of the biochemical processes involved in protein modification during apoptosis.

Main Results:

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  • Post-translational modifications, particularly those catalyzed by tissue transglutaminase, alter protein structures.
  • These modifications can enhance the immunogenicity of autoantigens.
  • Altered autoantigens may be more readily recognized by the immune system, potentially leading to autoimmunity.

Conclusions:

  • Post-translational modifications of proteins by tissue transglutaminase are implicated in the development of autoimmune diseases.
  • Understanding these modifications is crucial for developing targeted therapies for autoimmune conditions.