Related Experiment Videos
Tissue transglutaminase: apoptosis versus autoimmunity
1Dept of Biology, University of Rome Tor Vergata, Italy. mauro.piacentini@UniRoma2.it
Immunology Today
|April 22, 1999
Abstract:
Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the proapoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the proapoptotic enzyme tissue transglutaminase.