Overcoming inhibitions: subversion of CKI function by viral cyclins
1Gene Regulation Laboratory, ICRF, PO Box 123, Lincoln's Inn Fields, London, UK WC2A 3PX.
Abstract:
DNA tumour viruses deregulate the mammalian cell cycle to provide a better environment for their replication. Studies of such deregulation have led to the identification of key regulatory steps that normally control the G1-S phase transition of the cell cycle. The balance between the activities of G1-specific cyclin-CDK complexes and their inhibitors is critical. Recent studies suggest that certain herpesviruses disrupt this balance: the viruses encode a cyclin that generates active complexes even in the presence of high inhibitor levels.
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