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The emergence of physiological genomics
1Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisc., USA. cowley@mcw.edu
Journal of Vascular Research
|April 24, 1999
Summary
Physiological genomics is a new research approach to understand gene functions. This involves developing genomic and bioinformatics tools to map and identify gene functions across various organisms.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- The sequencing of the human genome and model organisms is revealing numerous new genes.
- Understanding the function of these genes is a critical challenge in modern biology.
Purpose of the Study:
- To discuss the current and developing genomic and bioinformatic tools for gene function identification.
- To explore the infrastructure needed for mapping and identifying gene functions.
- To address challenges in implementing functional genomics.
Main Methods:
- Review of existing and emerging genomic tools.
- Discussion of bioinformatic approaches for gene function analysis.
- Examination of infrastructure requirements for functional genomics.
Main Results:
- Genomic and bioinformatic tools are rapidly advancing.
- Infrastructure is emerging to support the mapping and identification of gene functions.
- Challenges exist in integrating these tools and infrastructure.
Conclusions:
- Physiological genomics requires new technological and organizational infrastructures.
- Linking genes to organismal function is the central goal.
- The field is rapidly evolving to meet these challenges.