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Updated: Aug 16, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
A new solid-phase synthesis of oligonucleotides 3'-conjugated with peptides
L De Napoli1, A Messere, D Montesarchio
1Dipartimento di Chimica Organica e Biologica, Università degli Studi di Napoli Federico II, Italy.
Abstract:
A convenient 'on line' solid-phase synthesis of oligonucleotides conjugated at the 3'-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3'-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry.
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