[Oxidative free radical processes and bioantioxidants during viral carcinogenesis]

The changes in biochemiluminescence intensity of tissue homogenates, tissue lipids as well as the values of the antioxidative activity of the free-radical processes regulators, bioantioxidants of lipids, and their antiradical activity were studied in viral carcinogenesis induced by Moloney's oncornavirus. Kinetics of biochemiluminescence of muscles homogenates and muscular tissue tumours (Moloney's sarcoma) and that of chemiluminescence of total lipids extracted from the muscular and tumour tissue were studied as well. A sharp increase in the intensity of lipids biochemiluminiscence and decrease in the tissue homogenates biochemiluminiscence were observed during the period of progressive tumour growth on the 6-8 days following introduction of the virus. At the same time the values of the antioxidative activity and antiradical activity of the tissue lipids bioantioxidants were minimal. Results of this investigation suggest that the expenditure of bioantioxidants are rather active during the period of progressive tumour growth. The regularities of the changes in biochemiluminescence intensity in the muscle tissue homogenates with viral carcinogenesis cannot be explained exceptionally by an increase in the amount of bioantioxidants in the tumour tissue lipids. Evidently the peculiarities of lipid-protein interactions might play an essential role in the mentioned process.