Related Experiment Video
Updated: Aug 29, 2026
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Animal model of bile duct dilatation created with minimally invasive surgery
Z Qian1, M Maynar, J Usón-Garallo
1Department of Radiology, Louisiana State University Medical Center, New Orleans 70112, USA.
Rationale And Objectives:
The purpose of the study was to evaluate a method of producing obstruction of the common bile duct and concomitant biliary duct dilatation in an animal model.
Materials And Methods:
Laparoscopic placement of a double-balloon occlusion device was used to produce common bile duct obstruction and bile duct dilatation in pigs.
Results:
One week after the procedure, common bile duct obstruction and dilatation of the biliary tree were demonstrated with either percutaneous transhepatic cholangiography or percutaneous cholecystography.
Conclusion:
The use of this method is technically feasible and provides a useful subacute and chronic animal model of common bile duct obstruction and dilatation of the biliary tree for percutaneous interventional training and research purposes.
