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Pharmacist-based i.v. theophylline therapy.

T Donahue, J Dotter, G Alexander

    Hospital Pharmacy
    |May 9, 1989
    PubMed
    Summary
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    A new protocol for intravenous theophylline dosing and monitoring was implemented. This approach ensured that 84% of patients remained within the target therapeutic range of 10-20 mcg/mL.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy Practice
    • Patient Safety

    Background:

    • Theophylline is a critical medication requiring careful dosing.
    • Inconsistent theophylline levels can lead to toxicity or sub-therapeutic effects.
    • A standardized protocol is needed for safe and effective IV theophylline administration.

    Purpose of the Study:

    • To implement and evaluate a protocol for intravenous theophylline dosing and monitoring.
    • To ensure consistent therapeutic theophylline levels in patients.
    • To improve patient safety and treatment efficacy.

    Main Methods:

    • Development and implementation of a pharmacist-driven protocol for IV theophylline.
    • Individualized dosing based on clinical criteria and patient history.

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  • Ongoing monitoring and dosage adjustments.
  • Quality assurance audits to assess adherence to therapeutic range.

    • Main Results:

    • The implemented protocol successfully maintained therapeutic theophylline levels (10-20 mcg/mL) in 84% of patients.
    • Pharmacist involvement ensured individualized dosing and monitoring.
    • Quality assurance audits validated the protocol's effectiveness.

    Conclusions:

    • A pharmacist-led protocol for IV theophylline dosing and monitoring is effective.
    • This protocol significantly improves the maintenance of therapeutic theophylline levels.
    • Implementation enhances patient safety and optimizes theophylline therapy.