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Physiologic effects of intense MR imaging gradient fields.

J D Bourland1, J A Nyenhuis, D J Schaefer

  • 1Department of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907-1297, USA. bourland@ecn.purdue.edu

Neuroimaging Clinics of North America
|May 11, 1999
PubMed
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Peripheral nerve stimulation from MRI pulsed magnetic fields is unlikely to cause cardiac issues. Human subjects experienced mild sensations at specific magnetic field gradient thresholds, with discomfort at higher intensities.

Area of Science:

  • Biophysics
  • Neuroscience
  • Magnetic Resonance Imaging (MRI)

Background:

  • Pulsed gradient magnetic fields in MRI can potentially stimulate peripheral nerves.
  • Understanding the relationship between magnetic field strength, duration, and nerve stimulation is crucial for MRI safety.

Purpose of the Study:

  • To quantify the strength-duration relationship for peripheral nerve stimulation induced by MRI pulsed gradient magnetic fields.
  • To establish thresholds for sensory perception and discomfort in human subjects.
  • To assess the risk of cardiac stimulation in animal models.

Main Methods:

  • Measured the strength-duration relationship in 84 human subjects using MRI pulsed gradient magnetic fields.
  • Fitted data to the hyperbolic strength-duration model: dB/dt=b(1 + c/d).

Related Experiment Videos

  • Conducted experiments in dogs to evaluate cardiac stimulation potential.

    • Main Results:

    • Determined average (rheobase, chronaxie) values for y-gradient (15 T/s, 0.37 ms) and z-gradient (26 T/s, 0.38 ms) for sensation threshold.
    • An intensity approximately 50% above the sensation threshold induced uncomfortable sensations.
    • Cardiac stimulation in dogs by pulsed magnetic gradient fields was found to be exceedingly unlikely.

    Conclusions:

    • Established quantitative parameters for peripheral nerve stimulation thresholds related to MRI gradient fields in humans.
    • MRI pulsed gradient fields at typical operating levels pose a very low risk for cardiac stimulation.
    • The findings support the continued safe use of MRI technology.