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Related Experiment Videos

Imaging techniques for assessing drug delivery in man.

Newman1, Wilding

  • 1Pharmaceutical Profiles Ltd, 2 Faraday Building, Highfields Science Park, University Boulevard, Nottingham, UK NG7 2QP.

Pharmaceutical Science & Technology Today
|May 14, 1999
PubMed
Summary

Gamma scintigraphy is the preferred in vivo imaging method for assessing oral and pulmonary drug delivery in pharmaceutical development. While 3D techniques like SPECT and PET offer advantages, practical challenges limit their use, making planar gamma scintigraphy the current standard.

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Area of Science:

  • Pharmaceutical Sciences
  • Medical Imaging
  • Drug Delivery Systems

Background:

  • In vivo imaging is crucial for pharmaceutical development.
  • Gamma scintigraphy (2D planar imaging) is widely used for oral and pulmonary drug delivery assessment.
  • 3D modalities like SPECT, PET, and MRI also have potential applications.

Purpose of the Study:

  • To evaluate the role of different in vivo imaging technologies in pharmaceutical development.
  • To compare the utility of gamma scintigraphy, SPECT, and PET for assessing drug delivery, particularly pulmonary deposition.

Main Methods:

  • Review of in vivo imaging techniques including gamma scintigraphy, SPECT, PET, and MRI.
  • Analysis of applications in pharmaceutical development, focusing on oral and pulmonary drug delivery.

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  • Comparison of advantages and practical limitations of each modality for drug delivery assessment.

    • Main Results:

    • Gamma scintigraphy is effective for visualizing and quantifying drug delivery via oral and pulmonary routes.
    • SPECT and PET offer potential benefits for regional lung deposition assessment from inhalers.
    • Significant practical challenges hinder the widespread application of SPECT and PET in routine studies.

    Conclusions:

    • Gamma scintigraphy remains the imaging modality of choice for assessing new oral and pulmonary drug product delivery.
    • Practical limitations currently outweigh the theoretical advantages of SPECT and PET for these applications.
    • Further advancements may be needed to overcome challenges associated with advanced 3D imaging in drug development.