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Topical anti-inflammatory activity of human recombinant epidermal growth factor
A Casacó1, N Ledón, A González
1Centro de Inmunología Molecular, Havana, Cuba. casaco@ict.cim.sld.cu
Skin Pharmacology and Applied Skin Physiology
|May 15, 1999
Abstract:
The topical anti-inflammatory activity of epidermal growth factor (EGF) was evaluated in inflammation models induced by 12-Otetradecanoylphorbol-13-acetate, croton oil and arachidonic acid. When EGF (1.5, 3 or 6 microg/ear) was coapplied with each inflammatory agent, there was a dose-related decrease in inflammation as assessed by ear punch weights, myeloperoxidase activity as well as by histopathological studies. The precise anti-inflammatory action of EGF is yet unclear, but we believe that interference with arachidonic acid metabolism may play an important role.