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Tissue engineering and the development of Apligraf a human skin equivalent
1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida, USA.
Advances in Wound Care : the Journal for Prevention and Healing
|May 18, 1999
Summary
Skin grafting has advanced from basic grafts to sophisticated tissue-engineered skin replacements. This review covers key developments, including cultured cells and matrices, leading to products like Apligraf.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Dermatology
Context:
- Skin grafting has evolved significantly over recent years.
- Early methods included autografts and allografts.
- Current advancements focus on biosynthetic and tissue-engineered skin replacements.
Purpose:
- To review the historical development of tissue-engineered skin replacements.
- To highlight key precursor technologies and their scientific rationale.
- To describe the technical innovations leading to Apligraf.
Summary:
- The review details the progression from cultured autologous and allogeneic keratinocyte grafts.
- It covers the development of acellular collagen and cellular matrices.
- The evolution culminates in the description of Apligraf, a tissue-engineered human skin product.
Impact:
- Provides a historical overview of tissue-engineered skin development.
- Explains the scientific basis for advanced skin replacement strategies.
- Offers insights into the creation of novel biomaterials for skin regeneration.