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Related Experiment Videos

Expression of the T-box gene Eomesodermin during early mouse development.

B G Ciruna1, J Rossant

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada.

Mechanisms of Development
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

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We identified the expression pattern of the mouse Eomesodermin (mEomes) gene. mEomes is initially found in extra-embryonic tissues and later in the developing brain, offering insights into early embryonic development.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The T-box gene family plays crucial roles in embryonic development.
  • Understanding the expression patterns of key developmental genes is essential for deciphering developmental processes.

Purpose of the Study:

  • To characterize the spatio-temporal expression pattern of the murine Eomesodermin (mEomes) gene.
  • To investigate the role of mEomes during early mouse embryogenesis.

Main Methods:

  • In situ hybridization was used to detect mEomes mRNA expression in mouse embryos.
  • Expression patterns were analyzed at various developmental stages, from pre-gastrulation to later embryonic development.

Main Results:

  • mEomes expression was first observed in the extra-embryonic ectoderm before gastrulation, persisting until head-fold stages.

Related Experiment Videos

  • Within the embryo proper, mEomes was detected in the primitive streak, nascent mesoderm, and anterior visceral endoderm.
  • A secondary expression domain for mEomes emerged in the telencephalon around embryonic day 10.5.

    • Conclusions:

    • mEomes exhibits dynamic expression during early mouse development, highlighting its potential roles in both extra-embryonic and embryonic tissues.
    • The distinct expression domains suggest mEomes involvement in multiple developmental processes, including early patterning and neurodevelopment.