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Splanchnic circulation is maintained during passive hyperventilation in orthotopic liver recipients
C G Krenn1, T Pernerstorfer, H Pokorny
1Department of Anesthesiology & General Intensive Care, University of Vienna, School of Medicine, Austria.
Acta Anaesthesiologica Scandinavica
|May 26, 1999
Summary
Short-term mechanical hyperventilation in liver transplant recipients did not significantly alter systemic circulation or graft function. This study found no adverse effects on indocyanine green kinetics or splanchnic oxygenation post-orthotopic liver transplantation.
Area of Science:
- Hepatology
- Transplantation Medicine
- Critical Care
Background:
- Mechanical hyperventilation reduces intracranial pressure in acute liver failure.
- Hyperventilation-induced hypocarbia may impact circulation and graft function post-orthotopic liver transplantation (OLT).
Purpose of the Study:
- To evaluate the effects of normocapnia and hypocapnia on systemic hemodynamics, splanchnic oxygenation, and graft function in OLT patients.
Main Methods:
- Measured systemic hemodynamics, gastric tonometry (splanchnic oxygenation), and indocyanine green kinetics (graft function) in 14 OLT recipients.
- Induced hypocapnia via mechanical hyperventilation to a PaCO2 of 4.2 +/- 0.4 kPa for approximately 1 hour.
Main Results:
- No statistically significant changes were observed in systemic hemodynamics.
- Splanchnic oxygenation and indocyanine green kinetics remained unchanged during short-term hyperventilation.
Conclusions:
- Short-term mechanical hyperventilation does not cause significant circulatory effects or alter graft function in the immediate postoperative period after OLT.
- Findings suggest hyperventilation is safe regarding circulatory and graft function in early OLT recovery.